Nucleotide Metabolism and Cancer Crossword Puzzle

QUESTIONS LIST:

• nucleotide: the monomer unit of dna and rna, linked by phosphodiester bonds.
• purine: a type of nitrogenous base with a two-ring structure, examples include adenine and guanine.
• gout: a painful disease caused by the accumulation of uric acid crystals in joints.
• allopurinol: a drug structurally similar to hypoxanthine, used to treat high uric acid levels by inhibiting xanthine oxidase.
• leukemia: a type of cancer characterized by the abnormal growth of white blood cells.
• pyrimidine: a nitrogenous base with a single-ring structure, such as cytosine, uracil, and thymine.
• uric acid: the final waste product of purine catabolism in humans, birds, reptiles, and insects.
• aminopterin: the first antifolic acid chemical, used by sydney farber in 1947 to treat acute lymphoblastic leukemia.
• methotrexate: an antifolic acid drug, similar in structure to aminopterin, that inhibits dihydrofolate reductase.
• thioredoxin: a protein that transfers electrons and protons to nucleoside diphosphate reductase during deoxyribonucleotide synthesis.